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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 4
First page : ( 979) Last page : ( 985)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00178.0

Development of Naratriptan Hydrochloride In-Situ Nasal Gel

Malekar Nikita S.1,*, Gondkar Sheetal B.1, Bhairav Bhushan A.1, Paralkar Pinak S.2, Saudagar Ravindra B.3

1Department of Quality Assurance Techniques, KCT'S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

2Department of Pharmaceutics, KCT'S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

3Department of Pharmaceutical Chemistry, KCT'S, Ravindra Gambhirrao College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

*Corresponding Author E-mail: nikitamalekarresearch @gmail.com

Online published on 17 July, 2017.

Abstract

Development of pH sensitive Naratriptan Hydrochloride in-situ nasal gel was aimed to improve absorption. In the present research work mixture of Carbopol-934 and Xanthan Gum were used to benefit pH sensitive gelation property. Different formulation were prepared by different concentrations of Carbopol-934 and Xanthan Gum. In this formulation the release profile depend on the concentration of Carbopol-934 and Xanthan Gum. These formulations were evaluated for parameters like pH, drug content, viscosity, mucoadhesive strength, gel strength, in-vitro drug release, and drug and excipients compatability. A 32 factorial design was applied to see the effect of various Carbopol-934 (X1) and Xanthan gum (X2) on the various models to a certain kinetic of drug release. Regression analysis and analysis of variance were performed for dependent variables. The study indicates that the formulation was effective in providing in-vitro release of drug and the mucoadhesive formulation. The objective of this study was to formulate a intranasal gel for drug targeting directly to brain via olfactory lobe pathway.

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Keywords

Anti-migraine, Carbopol-934, Xanthan Gum, In-Situ Gelling System, pH sensitive.

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