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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 3
First page : ( 833) Last page : ( 838)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00156.1

Formulation and Evaluation of Immediate release Tablets of Dasatinib using Croscarmelose Sodium

Sahoo Chinmaya Keshari1,*, Ramana D. Venkata2, Sahoo Nalinikanta3, Panda Kanhu Charan4, Panigrahy Uttam Prasad5

1Associate Professor, Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Hyderabad, Telangana-500014

2Professor, Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana-508252

3Associate Professor, Department of Pharmaceutical Analysis and Quality Assurance, MNR college of Pharmacy Fasalwadi, Sangareddy, Medak, Telangana, 502294, India

4Associate Professor, Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Rangareddy, Telangana, India

5Associate Professor, Department of Pharmaceutical Analysis and Quality Assurance, Malla Reddy College of Pharmacy, Maisammaguda, Hyderabad, Telangana-500014

*Corresponding Author E-mail: Sahoo.chinmaya83@gmail.com

Online published on 29 April, 2017.


The objective of the present study was to develop an immediate release tablet of Dasatinib using different concentrations of cross carmelose sodium (CCS) as superdisintegrant with a view to gain rapid disintegration in gastric pH for treatment of chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). Five different formulations of Dasatinib immediate release tablets were prepared using wet granulation method. Different pre compression and post compression characterization of tablet was carried out. In vitro drug release studies were carried out in USP II paddle type dissolution apparatus for different formulation and the batch containing 5% CCS gave maximum amount of drug release of 99.14%. Drug and excipients compatibility studies were carried out through FTIR spectroscopy. FTIR spectroscopy studies reveled that there is no interaction between drug and different excipients used in formulation. Short term stability studies (at 40±2ºC/75±5% RH) on the best formulation indicated that there no significant changes in drug content.



Immediate release tablets, Dasatinib, CCS, in vitro drug release study, FTIR spectroscopy.


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