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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 3
First page : ( 765) Last page : ( 768)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00143.3

Effects of L-lysine-α-Oxidase from Trichoderma In Vitro Experiments on the model of Viruses as Sindbis, Tick-borne encephalitis, West Nile, Tahyna and Dhori

Larichev V. F.1, Smirnova I. P.2, Syatkin S. P.2, Myandina G. I.2, Chibisov S. M.2, Ryskina E. A.2

1Federal State Budgetary Institution “Research Institute of Epidemiology and Microbiology named after Honorable Academician N. F. Gamaleya”, 16 Gamalei Str, Moscow

2Medical Department of Medical Institute of Peoples’ Friendship University of Russia, 3 Ordzhonikidze Str., Moscow

Corresponding Author E-mail: russia@prescopus.com

Online published on 29 April, 2017.


For the first time we studied the effect of the anticancer drug L-lysine-α-oxidase, obtained from culture liquid of Trichoderma harzianum Rifai F-180. In vitro experiments we established the high activity of L-lysine-α-oxidase in a model of tick-borne encephalitis and the lack of activity against viruses Sindbis, West Nile, Tahyna and Dhori.



L-lysine-α-oxidase, arboviruses, tick-borne encephalitis, cytopathic effect, antiviral activity.


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