Formulation and Evaluation of Orodispersible Tablets of an Antiulcer Agent
Sastry Srinivasa D1, Charyulu Narayana R2,*, Satyanarayana D S, Srilakshmi D
1Department of Pharmaceutics, Aditya College of Pharmacy, Surampalem, Rajahmundry, Andhra Pradesh, 533102, India
2Department of Pharmaceutics, N G S M Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka-575 018, India
*Corresponding Author E-mail: firstname.lastname@example.org
Online published on 29 April, 2017.
In the present work, an attempt has been made to formulate oral dispersible tablets of omeprazole by three different methods. Conventional tabletting procedure was followed for the preparation of tablets. Three batches omeprazole were prepared and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release, kinetics and stability studies. Formulations prepared by omeprazole superdisintegrants addition method emerged as the best formulations, as they showed rapid in vitro disintegration time, in vitro dispersion time and drug release at the end of 5 min, apart from taste and excellent mouth feel compared to other methods. It was concluded that oral dispersible tablets of anti ulcer agents can be successfully formulated and will be used as a novel drug dosage form for pediatrics and geriatrics with improved patient compliance.
Omeprazole, Orodispersible tablets, Superdisintegrants.