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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 3
First page : ( 739) Last page : ( 742)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00138.X

New Analytical Techniques for the Determination of Epalrestat in Pharmaceutical Dosage forms by Spectrophotometry

Annapurna Mukthinuthalapati Mathrusri*, Sushmitha Malineni, Anusha Kunala

Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, India

*Corresponding Author E-mail: mathrusri2000@yahoo.com

Online published on 29 April, 2017.

Abstract

Epalrestat is an aldose reductase inhibitor. Three simple, precise and accurate Spectrophotometric methods have been developed for the determination of Epalrestat in pharmaceutical formulations. Spectrophotometric analysis was performed and linearity was observed over the concentration range 0.1–25, 0.5–20 and 0.5–20 μg/ml in phosphate buffer (pH 5.0), phosphate buffer (pH 7.0) and borate buffer (pH 9.0) respectively. All the three methods were validated and can be used for the determination of Epalrestat in pharmaceutical formulations (Tablets).

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Keywords

Epalrestat, phosphate buffer and borate buffer, Spectrophotometry, Validation.

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