New Analytical Techniques for the Determination of Epalrestat in Pharmaceutical Dosage forms by Spectrophotometry
Annapurna Mukthinuthalapati Mathrusri*, Sushmitha Malineni, Anusha Kunala
Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, India
*Corresponding Author E-mail: firstname.lastname@example.org
Online published on 29 April, 2017.
Epalrestat is an aldose reductase inhibitor. Three simple, precise and accurate Spectrophotometric methods have been developed for the determination of Epalrestat in pharmaceutical formulations. Spectrophotometric analysis was performed and linearity was observed over the concentration range 0.1–25, 0.5–20 and 0.5–20 μg/ml in phosphate buffer (pH 5.0), phosphate buffer (pH 7.0) and borate buffer (pH 9.0) respectively. All the three methods were validated and can be used for the determination of Epalrestat in pharmaceutical formulations (Tablets).
Epalrestat, phosphate buffer and borate buffer, Spectrophotometry, Validation.