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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 3
First page : ( 683) Last page : ( 686)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00127.5

Dynamic Changes of the Microflora Sensitivity to Antibiotics in Patients with Chronic Calculous Pyelonephritis

Kulchenko N.G.1, Chibisov S.M.1, Eremina I.Z.1, Vekilyan M.A.2, Syatkin S.P.1, Skorik A.S.1, Myandina G.I.1, Shevkun N.A.1, Neborak E.V.1

1Federal State Budgetary Institution of Higher Professional Education “People's Friendship University of Russia”, Mikloukho-Macklay Street, 6, Moscow, 117198

2Department of Urology of Non-Governmental Healthcare, Institution of Regional Clinical Hospital at the station, Volgograd-1, JSC "Russian Railways", Avtotransportnaya Street, 75, Volgograd, 400131

Corresponding Author E-mail: russia@prescopus.com

Online published on 29 April, 2017.


Secondary pyelonephritis occurs in 48.3%-89.3% of cases and complicates the states of the disease. The effectiveness of therapy and prognosis of the disease depends on chosen methods of antibiotic prophylaxis of pyoinflammatory kidney diseases.

The purpose of the research

To improve the results of patients’ treatment with complicated calculous pyelonephritis.

Materials and methods

We have examined 179 people. This was a retrospective pharmacoepidemiological analysis of medical documents of patients, treated in 2009 and in 2013 in a hospital of Volgograd. The number of women, taking part in the research was 99 (55.4%) and men-80 (44%). All patients underwent a standard clinical examination, with the mandatory bacteriological urinalysis, renal ultrasound.


Among patients with chronic calculous pyelonephritis, the most common infectious agents are the following: E.coli-72, 4%, Staph. epidermidis-20, 8%, P. aeruginosa-26, 8%. The greatest sensitivity to infectious agents possess the next preparations: carbopenems (meronems)-92%, amoxicillin + clavulanic acid 86.4%, cefotaxime-89.4%. The greatest resistance of E. Coli is to ciprofloxacin and ampicillin.


The regular review of recommendations for antimicrobial therapy of urinary tract infections is necessary, due to the constant changes in the level of uropathogens resistance.



Urolithiasis, Calculous pyelonephritis, Antibiotic sensitivity.


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