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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 2
First page : ( 525) Last page : ( 528)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00104.4

Screening and Evaluation of Invasive Weeds against Pseudomonas aeruginosa (Mtcc 3541) for Quorum Sensing Interference and its Free Radical Scavenging

Arulmathi R1,*, Sudarmani D.N.P.2, Rajagopal K.1, Nagarajan T.3

1Department of Biotechnology, Vels University, Chennai

2Department of Biotechnology, Ayya Nadar Janaki Ammal College, Madurai

3Department of Molecular Biology, Madurai Kamaraj University, Madurai

*Corresponding Author E-mail: arulmathibioscience@gmail.com

Online published on 29 April, 2017.


Four invasive plants from the family of Amaranthaceae were challenged against Pseudomonas aeruginosa (MTCC 3541) for quorum sensing interference. Gomphrena serrata (seed), Digera muricata (flower) and Alternanthera paronychioides (leaf) showed elevated anti swarming activity 61.14%, 73.60% and 68.99% respectively when compared with control. All the concentrations of plant extracts used do not inhibit the growth but the quorum sensing. Significant scavenging activity of free radicals was observed with seed and flower extracts is above 97% of Alternanthera paronychioides and Digeria muricata flower showed 97% of scavenging free radicals. Biofilm (70.92%), pyocyanin (79.08%) and Las A (76.26%) production was inhibited to the significant level by Alternanthera paronychioides leaf, flower and leaf respectively. From the results analysed it is the property of plant compound to interfere quorum sensing but not the single part of the plant contribute all the phenomenon of quorum sensing inhibition but the whole plant may do the activity on further research.



Quorum sensing, Free radical scavenging, Invasive weeds.


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