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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 2
First page : ( 408) Last page : ( 413)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00082.8

Simultaneous Determination of Famotidine and Dicyclomine HCl in combined Tablet Dosage form by UV-Spectrophotometer

Wadher S J1,*, Kalyankar T M1, Kshirsagar J R1, Anitha K.2

1Department of Quality Assurance, School of Pharmacy, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606, (M.S.), India

2Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, Andhra Pradesh, India

*Corresponding Author E-mail: sjwadher@rediffmail.com

Online published on 29 April, 2017.


A simple, accurate, precise, and specific UV-Vis spectrophotometric simultaneous equation method has been developed for simultaneous determination of famotidine and dicyclomine HCl in its combined tablet dosage form by using methanol as a solvent. The proposed simultaneous equation method involves measurements of wavelength selected at 292 nm for famotidine and 218 nm for dicyclomine HCl. The linearity was found to be in the range of 20–120 μg/ml and 50–100 μg/ml for famotidine and dicyclomine HCl respectively. Beer's law was obeyed in this concentration range with correlation coefficient of 0.998 and 0.999 for famotidine and dicyclomine HCl respectively. The repeatability, Intra-day precision, Interday precision % RSD were found to be 0.140, 0.1305, 0.167 for famotidine and 0.180, 0.0321, 0.0472 for dicyclomine HCl respectively. Limit of detection and quantification was found to be 0.6944 μg/ml and 2.1044μg/ml for famotidine and 0.4446μg/ml for and 1.3474μg/ml for dicyclomine HCl respectively. Assay results for marketed formulation were found to be 98.91% and 101.83% for famotidine and dicyclomine HCl respectively. The proposed method has been validated as per ICH guidelines and successfully applied to the estimation of famotidine and dicyclomine HCl in their combined dosage form.



Famotidine, Dicyclomine Hydrochloride, Simultaneous equation method, UV Spectrophotometry and Forced degradation study.


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