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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 2
First page : ( 396) Last page : ( 400)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00080.4

UV-Spectrophotometric Estimation of Paliperidone by Derivative Method in Pharmaceutical Dosage Form

Rele Rajan V.*

Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai, 400016

*Corresponding Author E-mail: drvinraj@gmail.com

Online published on 29 April, 2017.

Abstract

The objective of the study was to develop a simple, accurate, precise and rapid a UV spectrophotometric i.e. second and third order derivative methods for the determination of paliperidone in pharmaceutical dosage form by using 0.1 N hydrochloric acid as a solvent. The method was further validated by ICH guidelines. The proposed derivative methods involve the measurement of absorbance at 252 nm for second order and 248.5 nm for third derivative for the estimation of paliperidone respectively. The linearity of the proposed method was found in the concentration range of 1 to 12 μg/ml (r2= 0.9995) for second order derivative and 1 to 12 μg/ml (r2= 0.9999) for third order derivative methods respectively. The percentage mean recovery was found to be 101.3117% for second order derivative and 99.428% for third order derivatives methods respectively. The methods were also statistically validated for its linearity, accuracy and precision. Both intra and inter day variations showed less percentage (%) RSD values indicating high grade of precision of this methods.

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Keywords

UV spectrophotometric estimation, derivative method, paliperidone.

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