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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 2
First page : ( 378) Last page : ( 380)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00076.2

Detection of FnbA gene encoding for fibronectin binding protein among clinical isolates of Staphylococcus aureus

Shah Khushali K.1,*, Dr. Gopinath P2

1BDS 2nd year, Saveetha Dental College, Saveetha University, Chennai

2Senior Lecturer, Department of Microbiology, Saveetha Dental College, Saveetha University, Chennai

*Corresponding Author E-mail: khushali.shah30@gmail.com

Online published on 29 April, 2017.

Abstract

Staphylococcus aureus is a major human pathogen associated with nosocomial respiratory tract infections in health care settings, particularly in critical care units. Pathogenesis of S. aureus is contributed to the expression of cell surface protein receptors for Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMMs) that interact specifically with proteins present in the host plasma and extracellular matrix.[1] Fibronectin-binding proteins (FnBPs) A and B are two of the multifunctional MSCRAMMs of S. aureus, which recognize fibronectin, fibrinogen, and elastin. In this study we have taken 20 clinical isolates of S. aureus which were subjected to antibiotic sensitivity pattern followed by the detection of fnbA gene by PCR. We have observed total resistance to penicillin followed by other group of drugs. 10% of our strains were found to have this gene. This indicates that the presence of this gene has the direct correlation with respiratory tract infections.

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Keywords

Staphylococcus aureus, fibronectin binding protein, PCR, fnbA gene.

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