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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 12
First page : ( 4313) Last page : ( 4316)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00789.2

Novel Spectrophotometric Method Development for the Estimation of Boceprevir in Bulk and in Pharmaceutical Formulations

Reddy P. Govardhan1, Kumar V. Kiran1, Raju VVSS Appala2, Ram J. Raghu3, Rraju N. Appala3,*

1Department of Pharmaceutics, Unity college of Pharmacy, Raigir (V), Bhongir (M), Yadagiri(D), Telanagan State

2Department of Chemistry, Faculty of Pharmacy, MAHSA University, Koula Lumpur, Malaysia

3Department of Pharmaceutical Chemistry, Sultan Ul-Uloom College Of Pharmacy, Mount Pleasant, 8-2-249, Road No.3, Banjara Hills, Hyderabad, Telangana-50034, India

*Corresponding Author E-mail: rajnemala25@gmail.com

Online published on 26 March, 2018.

Abstract

A New, Simple, Rapid and economical extractive spectrophotometric methods were developed for the determination of Boceprevir (anti-retroviral drug). Boceprevir is a direct acting protease inhibitor for the treatment of hepatitis C. It also has two isomers in which the S isomer is more active than the R-isomer. The methods were based on the formation of color chromogens with Bromo cresol green, Bromo thymol blue, Bromo phenol blue and Methyl orange indicator. The extractive spectrophotometry was carried out with phthalate buffer and chloroform. The absorbances of the chromogens were measured at 410 nm and 415 nm against the corresponding reagent blank. The proposed methods have been successfully applied to the bulk drug. The method has been statistically evaluated and was found to be precise and accurate.

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Keywords

Anti-hepatitis, Anti-HIV, Chromogen, Boceprevir, Extractive spectrophotometry, Victerelis®.

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