Users online: 1779    [ij] [ij] [ij] 
Email id

Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 12
First page : ( 4297) Last page : ( 4305)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00787.9

Association of Brain-Derived Neurotrophic factor (BDNF) gene SNP G196A with Type 2 Diabetes and Obesity: A Meta-Analysis

Ranjan Shovit, Sharma Praveen Kumar*

Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi-835205, Jharkhand, India

*Corresponding Author E-mail: pksharma.cuj@gmail.com

Online published on 26 March, 2018.


The aim of the study was to evaluate the association between diagnosis Type 2 Diabetes and Obesity (T2DO) and brain-derived neurotrophic factor (BDNF) gene polymorphism 196 G/A. The association between T2DO and the G196A polymorphism in the BDNF gene has already been investigated in several case-control studies, producing contradictory results. In order to explore these contradictory findings, the authors conducted a meta-analysis along with Trial Sequential Analysis (TSA) of BDNF 196 G/A polymorphism and T2DO in all the available case-control studies on the topic published from 2002 to 2016. We considered 8 case-control studies of the BDNF 196 G/A polymorphism associated with T2DO. Results showed significant association between BDNF 196 G/A allelic polymorphism and T2DO in Asian population. The present comprehensive meta-analysis suggested that further studies focusing on larger sample-size multi-ethnicity studies with homogeneous T2DO patients and well-matched controls are needed for future study to confirm the results of the study.



BDNF, G196A, Type 2 Diabetes, obesity, polymorphism, meta-analysis.


║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
642,388,128 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.