The Development of Industrial Technology of the Ointment Codenamed “Alergolik”
Rukhmakova O.A.*, Yarnykh T.G., Kovalenko S.N.
National University of Pharmacy, Ukraine, 61002, Kharkov, Pushkinskaya Str. 53
*Corresponding Author E-mail: email@example.com
Online published on 26 March, 2018.
The article is dedicated to development of industrial technology of the ointment codenamed “Alergolik”. To study the uniformity of distribution of medicinal substances and excipients in the drug the optimal time of the ointment's homogenization was found. The experiments showed that the ointment reaches homogeneity when it is stirring at 30 vol./min. by the frame stirrer during (20±2.5) min. Further stirring is impractical. Based on the complex of held biopharmaceutical, rheological and thermo gravimetric researches the rational technology of the ointment's preparation in industrial conditions was developed. The critical parameters in the process of production (mixing duration-(20±2.5) min., temperature of preparation-(50.0±5.0)°C, mixer mode-30 vol./min.) were set.
Dermatitis, ointment, research, industrial technology, critical parameters.