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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 12
First page : ( 4129) Last page : ( 4132)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00751.X

Nanotechnology with X-rays plays an essential role in improving radiation therapy for malignant breast cells

Saleh Nihad A.1, Wahid Talib A. Abdul2,*

1Babylon University-Science College-Physics Department, Iraq

2Kufa University-Science College-Physics Department, Iraq

*Corresponding Author E-mail: ltaliba.jabir@uokufa.edu.iq

Online published on 26 March, 2018.

Abstract

This research aims to enhance breast radiotherapy by increasing sensitivity enhancement ratio (SER). SER is the ratio of survival cells to initial cells for irradiation without and with NPs. The direct injection of nanoparticles into breast tumor considered a perfect method to increase SER. In this study AuNPS, GdNPs, AgNPs and TiNPs were used as radio-sensitizing agents to increase SER. The contrast agent loaded to breast tumor interacts with x-ray photons whose energy ranged from 2MeV to 20 MeV this led to enhance breast radio-sensitivity by increasing the absorbed dose due to the presence of high absorption coefficient elements. In this research, we get average SER from 10.79 to 13.50 depending on the type of contrast agent and x-ray energy.

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Keywords

Breast malignant, sensitivity enhancement ratio (SER), radio-sensitizing agent, mass energy absorption coefficient, NPs.

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