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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 11
First page : ( 3845) Last page : ( 3851)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00697.7

Characterization of Antifungal Metabolites Produced by Aeromonas Hydrophila and Analysis of its Chemical Compounds Using GC-MS

Kamal Sabreen A.1, Hamza Lena Fadhil2,*, Ibraheam Israa Adnan1

1Department of Biology, College of Science for women, University of Babylon, Iraq

2College of Pharmacy, University of Babylon, Iraq

*Corresponding Author E-mail:

Online published on 26 March, 2018.

Abstract

Bioactives were analyzed using gas chromatography-mass spectroscopy (GC-MS) techniques, then the in vitro antibacterial and antifungal activity of the methanolic extract was evaluated. Twenty three bioactive compounds were identified in the methanolic extract of Aeromonas hydrophila. GC-MS analysis of Aeromonas hydrophila revealed the existence of the Tricyclo[4.3.1.1(3, 8)]undecan-1-amine 1-Methyl-4-[nitromethyl]-4-piperidinol, Bicyclo[2.2.1]heptan-2-one, 4, 7, 7-trimethyl-, semicarbazone, D-Streptamine, O-6-amino-6-deoxy-α-Dglucopyranosyl-(1–4), 4-(2, 5-Dihydro-3-methoxyphenyl)butylamine, 3-Cyclohex-3-enyl-propionic acid, Benzenemethanol, 2-(2-aminopropoxy)-3-methyl-, Benzene, 1-methyl-4(4-morpholyl)ethenylsulfonyl-, Indan1, 2-dione, 4-methyl-, 2, 3-Dihydroindole-4-ol-2-one, 5, 7-dibromo-3, 3-dimethyl-, Benzamide, 3-amino-N-[4, 5dihydro-5-oxo-1-(2, 4, 6-trichlorop, 2-Acetonyl-9-[3-deoxy-β-d-ribouranosyl]hypoxanthine, DL-Leucine, Nglycyl-, 3-(2, 5-Dimethylanilinomethyl)-5-(3-fluorobenzylidene)-2, 4-thia, Benzenepropanoic acid, α(hydroxyimino)-, Butanoic acid, 4, 4′-dithiobis [2-amino-, [S-(R*, R*)]-N-Propionyl-D-glucosamine Actinomycin C2, N-(O-Nitrophenylthio)-l-leucine, D-Fructose, diethyl mercaptal, pentaacetate, 1H-Indole, 4-(3-methyl-2butenyl)-, Spiculesporic acid, 2, 5-Piperazinedione, 3, 6-bis(2-methylpropyl). Nerium olender (Alkaloids) was very highly active (5.408±0.24) mm. The results of anti-fungal activity produced by Aeromonas hydrophila showed that the volatile compounds were highly effective to suppress the growth of Aspergillus flavus (6.009±0.22). Aeromonas hydrophila produce many important secondary metabolites with high biological activities. Based on the significance of employing bioactive compounds in pharmacy to produce drugs for the treatment of many diseases, the purification of compounds produced by Aeromonas hydrophila can be useful.

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Keywords

Antifungal and antibacterial activity, Aeromonas hydrophila, GC-MS, Secondary metabolites.

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