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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 11
First page : ( 3807) Last page : ( 3809)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00691.6

A Prospective Study on Efficacy of Mircera for Treating Anemia Associated with Chronic Kidney Disease

Girisha K. Sai*, Dr. Ram Mohan

Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram, Chennai-600117, Tamilnadu, India

*Corresponding Author E-mail: girisha.pharmd17@gmail.com

Online published on 26 March, 2018.

Abstract

Background

Chronic kidney disease (CKD) is a risk factor for end-stage renal failure and cardiovascular events. High incidence of anaemia is found in CKD stage 3 and 4. MIRCERA a continuous erythropoietin receptor activator is in development to provide anaemia correction and stable maintenance of haemoglobin (Hb) levels at extended administration intervals in patients with chronic kidney disease (CKD). This study examined its efficacy when administered up to once monthly in patients with CKD.

Methodology

This study involved a prospective examination of haemoglobin levels in CKD patients by collecting and documentation the information of the patient including patient demographics, past medical history, medication history, and laboratory data. All enrolled patients were assessed for haemoglobin levels for every 4 weeks.

Results

The haemoglobin levels after 24 weeks treatment with Mircera were found to be significantly high when compared with baseline haemoglobin levels in CKD patients who didn't receive Mircera (P<0.0001).

Conclusion

Mircera demonstrated improved efficacy in treating anemia in patients with CKD when given twice weekly for 24 weeks.

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Keywords

Chronic kidney disease, Methoxy polyethylene glycol-epoetin beta, Anaemia, haemoglobin.

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