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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 11
First page : ( 3803) Last page : ( 3806)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00690.4

Assessment of Gremlin-1 Level in Pulmonary arterial hypertension disease

Al-Najeem Hadeel Thaeir, Al-Dujaili Arshad Noori Ghani*

Biology Department, Faculty of Sciences, University of Kufa, Iraq

*Corresponding Author E-mail: arshad.aldujaili@uokufa.edu.iq

Online published on 26 March, 2018.


In the current study, Fifty six patients of Pulmonary arterial hypertension were admitted from Echocardiography unit and Najaf Cardiac Centre in Al-Sadder Teaching City in Al-Najaf province/Iraq during September 2016 to February 2017, divided into six groups: -First group according to gender (Male= 34, Female = 22)Second group according to the type of disease, primary included 20 patients and secondary 36 group, Third group according to Smoking included smokers 26 subjects and nonsmokers patients group included 30 subjects, Fourth group according to the type of secondary pulmonary hypertension (Vulvular 24, Chronic Obstructive Pulmonary Disease 18 and Congenital 14), fifth group according to ages (30–39 year =12, 40–49 year = 12, 50–59 year= 12, 60–69 year = 20), six group according to Grades ([Mild = 18, moderate = 18, severe; 20).The control group was composed of thirty healthy subject. The results showed there was a significant increase (p<0.05) in Gremlin-1 serum level in patients of PAH in compared with healthy group, also the results revealed a significant increase (p<0.05) in Gremlin-1 in Males in compared with Females, Secondary PAH than Primary, smokers in compared with Nonsmokers. and Chronic Obstructive Pulmonary Disease compared with Congenital and Vulvular, Severe grades than Mild and Moderate and non significant differences between aged groups. Conclusion: The current results concluded that Gremlin-1 is a marker for detection and diagnosis of Pulmonary arterial hypertension.



Pulmonary arterial hypertension, Gremlin-1, Primary AH.


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