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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 11
First page : ( 3768) Last page : ( 3774)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00684.9

Design, Synthesis and Characterization of 2-pyridone Derivatives as C-Jun N-terminal Kinases (JNKs) Signaling Pathway Inhibitors

Mishra Prem Shankar1, Aanandhi M. Vijey2,*, Ravichandiran V.3

1Research Scholar, Department of Pharmaceutical Chemistry and Analysis, Vels University (VISTAS), Chennai-600117. Tamilnadu, India

2Department of Pharmaceutical Chemistry and Analysis, Vels University (VISTAS), Chennai-600117. Tamilnadu, India

3NIPER, Kolkata, India

*Corresponding Author E-mail: hodpchemistry@velsuniv.ac.in

Online published on 26 March, 2018.

Abstract

A new series of 2-pyridone derivatives (A1-A6) were synthesized by various substitution and their structures were confirmed by spectral and elemental analyses. The cytotoxic activities of the newly synthesized compounds were docked against JNKs (2WAJ Transferase). JNKs pathway regulates various physiological processes including inflammatory responses, cell differentiation, cell proliferation, cell death, cell survival and expression of proteins. The molecular docking study was used for confirming their interaction with c-Jun N-terminal kinases (JNKs). Through in silico molecular docking study, the result showed that all synthesized derivatives (A1-A6) have low binding energy (Table 1) and have good affinity toward their active pocket thus the synthesized derivatives were considered as good JNKs inhibitors. This will help to inhibit the outgrowth of cell and can be act as good anti cancer agents.

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Keywords

2-pyridone derivatives, JNKs signaling, Molecular docking methodology.

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