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To Enhance the Physicochemical Properties of Metoprolol Succinate By Co-Crystal Technique Mali Sachin S.*, Killedar Suresh G. Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India *Corresponding Author E-mail: sachinmali143@gmail.com
Online published on 26 March, 2018. Abstract Metoprolol succinate is a selective beta receptor blocker having poor physico-chemical and micromeritic properties. Therefore the co-crystals of metoprolol have been attempted to improve its physic-chemical and micromeritic characteristics. The effect of different co-formers such as benzoic acid and salicylic acid on flow ability of metoprolol by co-crystal technique. The co-crystals were characterized by Infra-red spectroscopy(I.R). It was found that micromeritic properties such as angle of repose, and physicochemical properties such as melting point. of co-crystals were significantly improved than that of pure metoprolol succinate. Hence it could be concluded that co-crystals could be one of the effective approaches for improved performance of metoprolol succinate. Top Keywords Co-Crystal Technique, Metoprolol succinate, Characterization of Co-Crystal etc. Top | |
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