(35.172.223.251)
Users online: 1691    [ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 11
First page : ( 3761) Last page : ( 3767)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00683.7

To Enhance the Physicochemical Properties of Metoprolol Succinate By Co-Crystal Technique

Mali Sachin S.*, Killedar Suresh G.

Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India

*Corresponding Author E-mail: sachinmali143@gmail.com

Online published on 26 March, 2018.

Abstract

Metoprolol succinate is a selective beta receptor blocker having poor physico-chemical and micromeritic properties. Therefore the co-crystals of metoprolol have been attempted to improve its physic-chemical and micromeritic characteristics. The effect of different co-formers such as benzoic acid and salicylic acid on flow ability of metoprolol by co-crystal technique. The co-crystals were characterized by Infra-red spectroscopy(I.R). It was found that micromeritic properties such as angle of repose, and physicochemical properties such as melting point. of co-crystals were significantly improved than that of pure metoprolol succinate. Hence it could be concluded that co-crystals could be one of the effective approaches for improved performance of metoprolol succinate.

Top

Keywords

Co-Crystal Technique, Metoprolol succinate, Characterization of Co-Crystal etc.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
574,687,197 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.