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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 11
First page : ( 3761) Last page : ( 3767)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00683.7

To Enhance the Physicochemical Properties of Metoprolol Succinate By Co-Crystal Technique

Mali Sachin S.*, Killedar Suresh G.

Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India

*Corresponding Author E-mail: sachinmali143@gmail.com

Online published on 26 March, 2018.


Metoprolol succinate is a selective beta receptor blocker having poor physico-chemical and micromeritic properties. Therefore the co-crystals of metoprolol have been attempted to improve its physic-chemical and micromeritic characteristics. The effect of different co-formers such as benzoic acid and salicylic acid on flow ability of metoprolol by co-crystal technique. The co-crystals were characterized by Infra-red spectroscopy(I.R). It was found that micromeritic properties such as angle of repose, and physicochemical properties such as melting point. of co-crystals were significantly improved than that of pure metoprolol succinate. Hence it could be concluded that co-crystals could be one of the effective approaches for improved performance of metoprolol succinate.



Co-Crystal Technique, Metoprolol succinate, Characterization of Co-Crystal etc.


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