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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 10
First page : ( 3492) Last page : ( 3497)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00625.4

In-vitro Characterization and Pharmacokinetic investigation of self-Micro-Emulsifying Tablets of Cinnarizine

Mishra Bibaswan1,*, Biswal Prasanta Kumar2, Pani Nihar Ranjan2, Dixit Prasanna Kumar3

1Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha, India

2Gayatri College of Pharmacy, Sambalpur, Odisha, India

3Department of Zoology, Berhampur University, Ganjam, Odisha, India

*Corresponding Author E-mail: drbibaswanmishra@gmail.com

Online published on 26 March, 2018.

Abstract

The present study aims to design and develop a self-micro-emulsifying tablets of cinnarizine with a suitable adsorbent of self microemulsion liquid to enhance the dissolution and oral bioavailability. The tablets were prepared by wet granulation compression of the self-micro-emulsifying granules. The granules were characterized through flow property. Droplet size distribution of disintegrated SMET emulsion sample was found to be within 3.86 ± 3.77 to 5.41 ± 2.93 μm which infers that all the SMETs showed good emulsification properties with low globule size. The tablets were tested for weight variation, friability, hardness, drug content, disintegration and in-vitro dissolution profile. The pharmacokinetic study of SMET of cinnarizine formulation was performed in rabbits and the pharmacokinetic parameters were compared with a piece of commercial tablet. The tablets showed acceptable physical properties with disintegration time less than 13 sec. The dissolution profile of selected formulation revealed more than 80 percent drug released in just 5 minutes. The pharmacokinetic parameters such as Cmax and AUC0-∞ of F7 found 1.5 and 1.8 times more than that of commercial product respectively. The results infer that the prepared of SMET formulation of cinnarizine is a potential formulation with profound reproducibility may be manufactured for commercial batch.

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Keywords

Self-micro-emulsifying tablets, In vitro dissolution, Oral bioavailability, Pharmacokinetic parameter, cinnarizine.

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