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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 10
First page : ( 3426) Last page : ( 3428)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00609.6

Biochemical and Histological Study of Royal Jelly in male rats induced by Oxidative Stress

Obaid Sarah Abbas, Jaffat Haider Salih, Shabaa Suhad Hamed

Biology Department, Faculty of Sciences, University of Kufa, Iraq

Corresponding Author E-mail: director.sps@velsuniv.ac.in, kamarapu.sudheerkumar@gmail.com

Online published on 26 March, 2018.

Abstract

The study was divided into six groups (5 rats in each group) for 8 weeks. Group 1: control animals give water and pellet kept it as negative group. Group 2: administrated CCl4 as in equal volume with olive oil (1/1) at 3 days in weeks. Group 3 and Group 4 were administrated royal jelly (RJ) at two concentrations 150, 300 mg/kg of body weight. Group 5 and Group 6 were administrated CCl4 along with royal jelly at two concentrations 150, 300 mg/kg of body weight respectively. At the end of experiment (60 days), rats was scarified, serum sample obtained for assessment of laboratory analysis the results show significant decrease (p<0.05) in liver function (AST, ALT and ALP) in groups treated with RJ at both doses 150, 300 mg/kg of body weight in compared with group treated with CCl4 only that has significant raise in AST, ALT and ALP levels and histological filed the result showed histological change include hepatocyte necrosis, sinusoidal vessels congestion and cytoplasmic vacuolization but, normal liver section n groups treated with RJ at both doses 150, 300 mg/kg of b.w.

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Keywords

RJ, CCl4, liver function.

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