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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 10
First page : ( 3260) Last page : ( 3263)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00578.9

Evaluation of Tumor Necrosis Factor-Alpha in Hepatitis C Virus with Diabetes Mellitus and Non Diabetes Mellitus patients

Mezher Musa Nima*, Jawad Dhuhah Hayder Abdul

College of Science-Kufa University-Iraq

*Corresponding Author E-mail: musan.alabbasi@uokufa.edu.iq

Online published on 26 March, 2018.


This study was conducted to detect the role Tumor Necrosis Factor-Alpha in Hepatitis C virus infected patients and type 2 diabetes mellitus induction. The study included 150 hepatitis C virus suspected patients attending Al-Hakeem Hospital/Central Laboratory in Al-Najaf province, over a period of 7 months from August (2014) to 7 February (2015), there ages ranged from (14–67) years old from both genders. Hepatitis C virus infection and diabetes mellitus detected based on clinical and laboratory investigations e, sixty four patients were found to be seropositive result to Hepatitis C virus, fourteen of HCV infected patients have type 2 diabetes mellitus and Eighteen individuals without any signs or symptoms of disease were selected as normal control group.

Serum level of tumor necrosis factor-alpha was measured through enzyme linked immunosorbant assay technique, the level of tumor necrosis factor-alpha showed a high significance (P<0.05) elevation in the serum of all patients than control. Also the hepatitis C virus with type 2 diabetes mellitus patients have an increased level of tumor necrosis factor-alpha (194.4pg/ml) than HCV patients without diabetes(124.6pg/ml), but these increase not significantly. Statistical analysis showed a positive association between HCV seropositive and tumor necrosis factor-alpha. Increment of serum level in HCV infected patients may lead to developed type 2 diabetes mellitus.



Hepatitis C Virus, Mellitus, Diabetes.


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