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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 10
First page : ( 3253) Last page : ( 3259)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00577.7

Design and Evaluation of Novel Oro-Dispersible Sustained Release Tablets of Poly Ethylene Glycol based Solid Dispersion of Domperidone

Beg Faiz Ahmed1, Pant Anjali2,*, Negi Jeetendra Singh3, Negi Vandana Jugran1

1Department of Pharmaceutical Sciences, S Bhagwan Singh PG Institute of Bio-medical Sciences and research, Balawala, Dehradun-248161, Uttarakhand, India

2Department of Pharmaceutical Sciences, S Bhagwan Singh PG Institute of Bio-medical Sciences and research, Balawala, Dehradun-248161, Uttarakhand, India

3Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, UCSI University. No 1, Jalan Menara Gading, UCSI Heights, 56000 Cheras, Kuala Lumpur, Malaysia

*Corresponding Author E-mail: anjali4354@rediffmail.com

Online published on 26 March, 2018.

Abstract

Solid dispersion has been widely used as cost efficient solubility enhancement technique for poorly watersoluble drugs. Domperidone (DOM) is practically insoluble in water which resulted in its poor oral bioavailability. Solid dispersion of DOM with poly ethylene glycol 4000 (PEG) in 1: 3 was prepared by melting method to improve solubility of DOM. Solid dispersions were characterized by FTIR, DSC and XRD techniques. Further solid dispersion of DOM was treated with molten lipid to form solid dispersion based sustained release (SDSR) granules. The integrity of solid dispersion in SDSR granules was also investigated by XRD studies. Drug release from SDSR granules was sustained up to 12 hrs. Finally, orodispersible (OD-SDSR) tablet of SDSR granules were prepared in order to improve patient compliance. The optimum formulation was rapidly disintegrated within 40 seconds.

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Keywords

Domperidone, solid dispersion sustained release (SDSR) granules, OD-SDSR, oro-dispersion, PEG based solid dispersion.

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