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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 1
First page : ( 174) Last page : ( 176)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00038.5

Evaluation of Anti-Inflammatory effect of 4-Benzylpiperidine using Membrane Stabilization Method-an Invitro Study

Jayashree V.1,*, Karthick L.2, Thenmozhi N.1, Sangeetha1

1School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram, Chennai, 117, Tamil Nadu

2Jaya College of Pharmacy, Thiruninravur, Chennai, Tamil Nadu, 602 024

*Corresponding Author E-mail: vjayashree@gmail.com

Online published on 29 April, 2017.

Abstract

The objective of this study was to evaluate the anti-inflammatory potential of 4-Benzylpiperidine. The antiinflammatory activity was evaluated using invitro models such as heat induced membrane stabilization method, hypotonicity induced membrane stabilization method at different concentrations. Aspirin were used as standard drugs. The percentage of inhibition was compared with those of standard drugs. The results indicate that the 4benzylpiperidine possess anti-inflammatory properties. The mode of action of the test sample and standard antiinflammatory drugs could be connected with binding to the erythrocyte membranes with subsequent alteration of the surface charges of the cells. Protective effect on heat and hypotonic saline, induced erythrocyte lysis is known to be a good index of anti-inflammatory activity of any agent. So 4-Benzylpiperidine can be used as a potential source of anti-inflammatory agents.

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Keywords

Anti-Inflammatory Activity, 4-Benzylpiperidine, Membrane Stabilization.

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