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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 1
First page : ( 31) Last page : ( 34)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00008.7

Spectrophotometric Estimation of Paliperidone in Bulk Drug and Pharmaceutical Dosage Form by Area Under Curve Method

Rele Rajan V.*

Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai-400016

*Corresponding Author E-mail: drvinraj@gmail.com

Online published on 29 April, 2017.

Abstract

A simple and precise UV-spectrophotometric method, area under curve [AUC], has been developed and validated for the estimation of paliperidone in bulk drug and its pharmaceutical formulation. Paliperidone was estimated by area under curve (AUC) method for the zero order spectrums in between 234 nm to 242 nm. Beer's law was obeyed in the concentration range of 1 to 14 μg/ml with coefficient of correlation value 0.9996. This method was tested and validated for various parameters according to ICH guidelines. The precision expressed as relative standard deviation, which was within the range of 0.1460% to 0.4589% for the above method. The proposed method was successfully applied for the determination of paliperidone in pharmaceutical formulation. Results of the analysis were validated statistically and were found to be satisfactory. The proposed method is simple, easy to apply, low-cost and require relatively inexpensive instruments.

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Keywords

Paliperidone, Area under curve method.

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