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Research Journal of Pharmacy and Technology
Year : 2008, Volume : 1, Issue : 4
First page : ( 487) Last page : ( 491)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

Cardioprotective effect of ethanol extract of stem-bark and stem-wood of Premna serratifolia Lin., (Verbenaceae)

Rajendran Rekha1,*, Basha N. Saleem2

1Department of Pharmacognosy, Mohamed Sathak A. J. College of Pharmacy, Medavakkam, Chennai -600 119, India

2Department of Pharmaceutical Biotechnology, Mohamed Sathak A. J. College of Pharmacy, Medavakkam, Chennai -600 119, India

*Corresponding Author E-mail: rekhacognosy@rediffmail.com

Abstract

Cardioprotective effect of ethanol extract of Premna serratifolia Lin., was tested on Isoproterenol administered experimental myocardial infarction in rats and was confirmed by ECG study in rat heart, electrophoresis analysis of serum protein, serum A/G ratio, biochemical studies such as heart tissue proteins, glycogen, nucleic acids and blood glucose. Subcutaneous injection of Isoproterenol (20mg/100g body weight in 0.1ml saline) to rats for 2 consecutive days caused myocardial damage and was confirmed by elevation of ST segments in rat heart ECG pattern, reduction in serum electrophoresis protein bands and serum A/G ratio, increase in heart tissue proteins and nucleic acids, increase in blood glucose and decrease in heart tissue glycogen. Pretreatment with ethanol extract (100mg/100g body weight in 0.2ml of 5% gum acacia) for 28 days through intraperitoneal injection in Isoproterenol administered rats produced these parameters from alteration as compared with myocardial infarcted rats. This confirmed the cardioprotective effect of ethanol extract of Premna serratifolia Lin., on Isoproterenol induced myocardial infarction in rats and the protective myocardial effect may be due to the phytoconstituents like iridoid glycosides, alkaloids, flavonoids and phenolic compounds present in it.

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Keywords

Premna serratifolia Lin, ethanol extract, ECG, Isoproterenol, myocardial infarction, serum A/G ratio, proteins.

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