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Research Journal of Pharmacy and Technology
Year : 2008, Volume : 1, Issue : 4
First page : ( 398) Last page : ( 400)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

Hepatoprotective Activity of Aerva lanata Linn. Against Paracetamol Induced Hepatotoxicity in Rats

Manokaran S1,*, Jaswanth A1, Sengottuvelu S2, Nandhakumar J2, Duraisamy R2, Karthikeyan D2, Mallegaswari R3

1Srikrupa Institute Pharmaceutical Sciences, Velkatta Village, Medak District, Andhra Pradesh, India

2Nandha College of Pharmacy and Research Institute, Koorapalayam Pirivu, Perundurai Main Road, Erode-638052

3KM College of Pharmacy, Melur Main Road, Uthankudi Post, Madurai-625107, Tamil Nadu, India

*Corresponding Author E-mail: msellimuthu@gmail.com

Abstract

The present study was conducted to evaluate the hepatoprotective activity of hydroalcoholic extract of Aerva lanata against paracetamol induced liver damage in rats. The hydroalcoholic extract of Aerva lanata (600mg/kg) was administered orally to the animals with hepatotoxicity induced by paracetamol (3gm/kg). Silymarin (25mg/kg) was given as reference standard. All the test drugs were administered orally by suspending in 0.5% Carboxy methyl cellulose solution. The plant extract was effective in protecting the liver against the injury induced by paracetamol in rats. This was evident from significant reduction in serum enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin. It was concluded from the result that the hydroalcoholic extract of Aerva lanata possesses hepatoprotective activity against paracetamol induced hepatotoxicity in rats.

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Keywords

Aerva lanata, Paracetamol, hepatoprotetive, hepatotoxicity.

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