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Research Journal of Pharmacology and Pharmacodynamics
Year : 2016, Volume : 8, Issue : 4
First page : ( 151) Last page : ( 156)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2016.00027.6

Activity of Ganoderma lucidum on Serum Marker Enzymes in Ochratoxin a treated albino rat models

Orole Olukayode Olugbenga*, Uyi Gerard O., Gbadeyan Ayofemi F.

Federal University Lafia, Nigeria

*Corresponding Author E-mail: orolekayode@yahoo.com

Online published on 2 February, 2017.


The study aims to determine the effects of Ganoderma lucidum in altering serum enzymes in ochratoxin A intoxicated albino rats. Animals were divided into six groups of seven rats and administered different concentrations of OTA and crude extract of the fungus while ochratoxin A doses were administered intraperineally once. The blood urea content after sacrificing was between 0.8±6.5 mg/dL and 20.2±5.8 mg/dL, alkaline phosphatase recorded the highest value for animals in Group 6 (98.3±2.9 U/L) with both enzymes being significantly different at p=0.05 within the groups. The serum globulin values were 39±1.8 g/L (control), 49.3±0.9 g/L (group 4), and 49.7±0.88 g/L (group 3). Alanine aminotransferase levels were significantly different from group to group at p=0.05 with animals in group 5 giving the highest value 64.3±1.8 U/L. Serum aspartate aminotransferase recorded the highest value for animals in Group 3 (109.3±1.5 U/L). The study showed that G. lucidum have the capacity to effect ameliorative, healing, scavenging, and restoring activities on serum enzymes which ultimately will improve the total well being of animals exposed to ochratoxin A, but at the same time, the challenge of weight loss resulting from food withdrawal need to be addressed.



Ganoderma, Albino Rats, Intoxicated, Intraperineally, Scavenging.


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