Hypolipidemic and Antioxidant Activity of Methanolic Leaf Extract of Ochna obtusata on High Fat Diet Induced Obesity in Rats Gangoni Ashwini*, Suneetha B, Sunanda S, Ravindrababu S Malla Reddy Institute of Pharmaceutical Sciences, Dhulapally, Secundrabad *Corresponding Author E-mail: gangone.ashwini22@gmail.com
Online published on 2 May, 2015. Abstract In the present study, the methanolic extract of Ochna obtusata leaves (MEOOL) was evaluated for hypolipidemic and antioxidant activity in high fat diet (HFD) induced model. In the present study, chronic administration of High fat diet (HFD) in rats produced significant increase in the body weight, total cholesterol (TC), high density lipoprotein (HDL), very low density lipoproteins (VLDL), low density lipoproteins (LDL), triglycerides (TG) and blood glucose levels. Treatment of obese rats with MEOOL for 28 days resulted in a significant (p < 0.001) change in the body weight, and biochemical parameters estimated. The extract also showed a significant antioxidant activity. The levels of lipid peroxidation (LPO) and superoxide dismutase (SOD) significantly get redued and the levels of reduced glutathione (GSH) and catalase was increased significantly indicating the extract is having potent antioxidant status. Further rats treated with MEOOL show reduced atherogenic index. The current study provides a strong evidence that MEOOL has a beneficial effect in treating hyperlipidemia and oxidative stress at the dosage and duration study. Top Keywords Hyperlipidemia, High fat Diet, Ochna obtusata, HDL, LDL, VLDLD, Antioxidants. Top |