(3.239.91.5)
[ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacology and Pharmacodynamics
Year : 2013, Volume : 5, Issue : 6
First page : ( 313) Last page : ( 316)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.

Assessment of Hepatoprotective Activity of Hibiscus vitifolius leaves in CCL4 induced hepatotoxic rats

Samal Pradeep Kumar*

SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh

*Corresponding Author: Pradeep Kumar Samal, Assistant Professor, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh

Online published on 3 February, 2014.

Abstract

The objective of this study was to investigate the hepatoprotective activity of alcoholic extract of Hibiscus vitifolius leaves against carbon tetrachloride (CCl4) induced hepatotoxicity. The plant material were dried in shade then powdered and extracted with alcohol. Preliminary phytochemical tests were done. Alcoholic extract showed presence of phenolic compound and flavanoids. The hepatoprotective activity of the alcoholic extract was assessed in CCl4 induced hepatotoxic rats. Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALP, Billirubin and Protein were tested in both CCl4 treated and untreated groups. CCl4 (1ml) has enhanced the SGOT, SGPT, ALP and Total Billirubin where decrease in total protein level in liver. Treatment of alcoholic extract of Hibiscus vitifolius (500mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner. Our findings suggested that Hibiscus vitifolius alcoholic leaves extract possessed hepatoprotective activity.

Top

Keywords

Hibiscus vitifoliusHepatoprotectiveSilymarin, CCl4, alcohol.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
739,711,589 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.