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Research Journal of Pharmacology and Pharmacodynamics
Year : 2012, Volume : 4, Issue : 5
First page : ( 315) Last page : ( 318)
Print ISSN : 0975-4407. Online ISSN : 0000-0000.

Evaluation of anti-obesity activity of Lantana camara var Linn on butter induced Hyperlipidemia in Rats

Gundamaraju Rohit1,*, Atigari Diana Vivian1, Mrs. Sheeba D. S. Helen1, Dr. C. Ramesh2

1Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally (Post via Hakimpet), Secunderabad (500014) AP, India.

2GSN Pharmaceuticals Pvt. Ltd., Rajeev Gandhi Nagar, Kukatpally, Hyderabad (500072), Andhra Pradesh, India.

*Corresponding Author: Rohit Gundamaraju, Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Hyderabad-500060, A.P E-mail: rohit.gundamaraju@gmail.com

Online published on 21 February, 2013.

Abstract

The hypolipidemic activity of Lantana camara was studied on high fat diet induced models of hyperlipedemia in rats. Hyper lipidemia condition established by butter was evidenced by enhancement in levels of cholesterol, tri-glycerides, LDL, VLDL. Methanolic extract showed significant hypolipidemic effect by lowering of serum levels of serum cholesterol, TG, LDL, VLDL and increased dl level. Ethanobotanical knowledge of medicinal plants is some of the most prominent source of new drugs and has shown potential results for treatment of obesity. Prelimnary phytochemical analysis revealed thye presence of phyto constituents such as steroids, flavinoids, alkaloids.

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Keywords

High fat diet, Lantana camara, obesity.

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