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Research Journal of Pharmacology and Pharmacodynamics
Year : 2012, Volume : 4, Issue : 5
First page : ( 307) Last page : ( 310)
Print ISSN : 0975-4407. Online ISSN : 0000-0000.

Evaluation of Gastroprotective Effect of Aqueous Leaf Extract of Commicarpus chinensis in Pylorus Ligted Albino Rats

Halkai M.A., Mahurkar Nitin, Ahmed M.D. Akhil*, Beknal A.K., Hasan S.M. Sayeed Ul, Swathi M.

Department of Pharmacognosy, H.K.E. ’s MTR IPS, Gulbarga – 585 105

*Corresponding Author: M.D. Akhil Ahmed, Department of Pharmacognosy, HKES MTR IPS, Sedam Road, Gulbarga – 585 105. Email: mdakhilahmed@gmail.com Phone: 07899764940

Online published on 21 February, 2013.

Abstract

Objective

To evaluate the gastroprotective effect of aqueous extract of leaves of Commicarpus chinensis in pylorus ligated albino rats.

Materials and Methods

The plants were collected from the campus Gulbarga University, Gulbarga, Karnataka and authenticated by department of Botany, Gulbarga University, Gulbarga. The leaves were shade dried and subjected to extraction by percolation to obtain aqueous extract. The aqueous extract was evaluated for antiulcer activity by pylorus ligation model in albino rats. Albino rats of either sex weighing between 180–220 g were procured from the Central animal house, MR medical college, Gulbarga, Karnataka. The animals were divided into three groups of six animals in each. The animals were fasted for 48h and subjected to pylorus ligation technique for evaluating the antiulcer effect of C. chinensis. Prior approval of the IAEC was obtained for conduction of experiment.

Results

The aqueous leaf extract showed significant antiulcer activity on comparison with that of standard rabeprazole. The aqueous extract reduced the acidity of gastric juice and increased the pH of the gastric secretions, exhibiting statistically significant ulcer protection activity.

Conclusion

The antiulcer effect of C.chinensis may be due to antioxidant property contributed by the presence of tannins, flavonoids, saponins. Thus, C.chinesis possesses effective antiulcer property.

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Keywords

Commicarpus chinesis, Pylorus ligation, Rabeprazole, Antiulcer activity.

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