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Research Journal of Pharmacology and Pharmacodynamics
Year : 2012, Volume : 4, Issue : 4
First page : ( 233) Last page : ( 235)
Print ISSN : 0975-4407. Online ISSN : 0000-0000.

Evaluation of Antitussive Activity of Alternanthera sessilis

Venkatesh A.1,*, Silambujanaki K.1, Raju D.1, Elumalai A.2

1Department of Pharmacology, SRM College of Pharmacy, Kattankulathur, Kancheepuram Dt, Tamil Nadu, India, 603 319

2Department of Pharmacognosy, SRM College of Pharmacy, Kattankulathur, Kancheepuram Dt, Tamil Nadu, India, 603 319

*Corresponding Author: A. Venkatesh, Department of Pharmacology, SRM College of Pharmacy, Kattankulathur, Kancheepuram Dt, Tamil Nadu, India, 603 319 E-mail: venkateshrx87@gmail.com

Online published on 21 February, 2013.

Abstract

The aim of the present study was to look at the antitussive activity of the ethanol extract of Alternanthera sessilis whole plant (EAS) by Sulfur dioxide gas induce model in mice. Results were revealed that the MESI was found to produce significant antitussive activity when compared with control and codeine phosphate in a dose dependent manner. The EAS produced 51.1 and 29.2% inhibition of SO2 induced cough at doses of 250 and 500mg/kg respectively the standard antitussive drug codeine phosphate(10 and 20mg/kg.p.o) showed 45.2 and 25.3% inhibition respectively.

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Keywords

Alternanthera sessilis, antitussive activity, Sulfur dioxide gas induce model in mice.

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