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Research Journal of Pharmacology and Pharmacodynamics
Year : 2012, Volume : 4, Issue : 4
First page : ( 206) Last page : ( 209)
Print ISSN : 0975-4407. Online ISSN : 0000-0000.

Evaluation of Hepatoprotective Activity of Blumea mollis D. Don Merr. on Paracetamol-Induced Hepatotoxicity in Rats.

Devi G.B. Brindha1,*, Revathi K.2

1Assistant Professor, Department of Zoology, Government College for Women (Autonomous) Kumbakonam, Tamil Nadu, India.

2Reader, Department of Advanced Zoology and Biotechnology, Ethiraj College, Chennai, Tamil Nadu, India

*Corresponding Author: Brindha Devi. G. B., Assistant Professor, Department of Zoology, Governmnet College for Women (Autonomous) Kumbakonam, Tamil Nadu, India. Email: brindhasrm@gmail.com

Online published on 21 February, 2013.

Abstract

The therapeutic values of numerous plants and their herbal formulations were tested against a few chemical induced subclinical levels of liver damages in rodents and experiments have clearly shown that plants such as Picorrhiza kurroa, Andrographis paniculata, Eclipta alba, Phyllanthus maderaspatensis and Trichopus zeylanicus are sufficiently active against certain hepatotoxins. Screening plants for antihepatitis activities remains in its infancy. The Methanol extract of Blumea mollis were studied for their hepatoprotective effects on paracetamol induced acute liver damage on Wistar albino rats. The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP and bilirubin Further, the effects of the extract on hepatic Glycogen (mg/100g tissue) GSH (nmlol/mg protein GST (u/g tissue), GPX (u/mg protein) GSH-R (μmol NADPH min −1/g tissue) were estimated. The Blumea mollis extracts produced significant (P <0.05) hepatoprotection by decreasing the activity of serum enzymes and bilirubin while it significantly increased the levels of Hepatic glycogen reduced glutathione (GSH) Glutathione-S-transferase (GST) glutathione peroxidase (GPX) and GSH-R in a dose dependent manner.

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Keywords

Blumea, hepatoxicity, serum marker enzymes, liver diseases, herbal medicines.

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