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Research Journal of Pharmacology and Pharmacodynamics
Year : 2012, Volume : 4, Issue : 2
First page : ( 84) Last page : ( 86)
Print ISSN : 0975-4407. Online ISSN : 0000-0000.

Diuretic activity of whole plant extract of Leptadenia reticulata

Mohanraj S.1,*, Santhoshkumar C.2, Chandran A.3

1Jogaiah Institute of Technology and Sciences, College of Pharmacy, Kalagampudi, Andhra Pradesh, India

2Srikrupa Institute of Pharmaceutical Sciences, Siddipet. Andhra Pradesh, India

3PGP College of Pharmaceutical Science & Research Institute, Namakkal, India

*Corresponding Author: Mr. S. Mohanraj M.Pharm, Assistant Professor, Jogaiah Institute of Technology and Sciences, College of Pharmacy, Kalagampudi, Andhra Pradesh, India Mobile No: 08008928921. Email: mohanmani_50@yahoo.com

Online published on 21 February, 2013.


The present study was undertaken to investigate the diuretic effect of aqueous and ethanolic extract of the Whole plant of Leptadenia reticulata in normal rats. Aqueous and ethanolic extracts of whole plants of Leptadenia reticulata were administered to experimental rats orally at doses of 100mg/kg p.o. Furosemide (100 mg/kg) was used as positive control in study. The diuretic effect of the extract was evaluated by measuring urine volume, sodium, potassium and chloride content. Urine volume was significantly increased by both aqueous and ethanolic extract in comparison to the control group but this effect was less than furosemide. Significant increase in renal clearance of sodium, potassium and chloride ions was observed in treated and standard groups.



Diuretic activity, Furosemide, Leptadenia reticulataaqueous and ethanol.


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