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Research Journal of Pharmacology and Pharmacodynamics
Year : 2011, Volume : 3, Issue : 5
First page : ( 281) Last page : ( 284)
Print ISSN : 0975-4407.

Hepatoprotective Potentials of Butea monosperma Stem Bark Extract against Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats

Tiwari Prashant1,*, Kumar Kuldeep2, Panik Rajnikant3, Pandey Alok4, Pandey Ashish4, Sahu Pratap Kumar5

1Pinnacle Biomedical Research Institute, Bhopal, Madhya Pradesh, India

2Smt. Vidyawati Collage of Pharmacy, Jhansi (Uttarpradesh)

3Gover. Girls Polytechnic College, Raipur (Chhattisgarh)

4Raipur Institute of Technology, Raipur (Chhattisgarh)

5Siksha ‘O’ Anusandhan University, Bhubaneswar, Orissa

*Corresponding Author: Prashant Tiwari Pinnacle Biomedical Research Institute Bhopal, Madhya Pradesh, India. Email-ptc_ptc15@rediffmail.com Contact-09039488979

Online published on 20 March, 2013.

Abstract

Carbon tetrachloride (CCl4) pharmacological tool to produce liver damage in rats. Silymarin (100 mg/kg) and extract of Butea monosperma (shown to be hepatoprotective substances) prevented the CCl4 induced toxicity. Hydroalcholic extract of the stem bark of Butea Monosperma was evaluated for its hepatoprotective. This in vitro efficacy was reinforced by a significant dose dependent hepatoprotection (at 100 mg/kg and 200mg/kg dose) by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation while it significantly increased the reduced Glutathione levels of tissue in a dose dependant manner. The Hepatoprotective activities of the extract are being comparable to standards Silymarin. The results obtained in the present study indicate that stem bark extract of Butea Monosperma is a potential source of natural hepatoprotective. The hepatoprotective property may be attributed to the antioxidant potential and the phytochemical constituents of the plant. The present study justifies the claim of the native practitioner that the decoction of the plant is useful in treating jaundice and find out the clinical efficacy of the Butea Monosperma.

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Keywords

Carbon tetrachloride, Butea monosperma, Silymarin, Alanine amino transferase, Glutathione, Serum glutamate oxaloacetate transaminase, Serum glutamate pyruvate transaminase, Hepatoprotection.

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