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Research Journal of Pharmacology and Pharmacodynamics
Year : 2011, Volume : 3, Issue : 1
First page : ( 19) Last page : ( 21)
Print ISSN : 0975-4407.

Hepatoprotective Effect of Pergularia daemia on Cadmium Chloride Induced Toxicity in Rats

Kumar P. Vinoth1,*, Kumar Ch. Sudheer2, Selvi V. Veera Thamarai1, Bricey A. Amala3

1Department of Biotechnology, J.J college of Arts and Science, Pudukottai, India

2Department of Biotechnology, School of Life Sciences, University College of Engineering, JNTU, Kakinada, Andhra Pradesh, India

3Department of Biotechnology, Bharathidasan University, Trichy, India

*Corresponding Author: P. Vinoth Kumar, Department of Biotechnology, J.J college of Arts and science, Pudukottai, India, E-mail: vinothkumarphd@gmail.com, Tel: 09943451023.

Online published on 20 March, 2013.


The present study was undertaken to examine the inhibitory effect of the Pergularia daemia on cadmium chloride induced hepatoprotective activity in liver. In rats injected with cadmium chloride, the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), γ -glutamyl transferase (GGT) was significantly (p < 0.05) increased when compared to those values in control rats. The rats administrated with P.daemia extract and cadmium chloride showed a significantly (p < 0.05) decreased levels of serum AST, ALP, LDH and GGT. This study suggested that P.daemia may be implicated as a hepatoprotective agent for therapeutic purposes.



Cadmium chloride, Hepatoprotective activity, Pergularia daemia.


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