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Research Journal of Pharmacology and Pharmacodynamics
Year : 2010, Volume : 2, Issue : 3
First page : ( 239) Last page : ( 242)
Print ISSN : 0975-4407.

Hepatoprotective Activity of Bauhinia variegata Bark against Carbon Tetrachloride Induced Hepatotoxicity in Female Albino Wistar Rats.

Jadhav Anil G.1,*, Narkhede Sachin B.2, Patil Mrutyunjay B.1, Vidyasagar G.3

1Dept. of Pharmacognosy, KLES College of Pharmacy, Belgaum, Karnataka, India

2Dept. of Pharmacognosy, Smt.BNB Swaminarayan Pharmacy College, Salvav (Vapi)

3Veerayatan Institute of Pharmacy, Jakhania, Bhuj-Mandvi Road, Kutch-370460, Gujarat, India

*Corresponding Author: Jadhav Anil G. Dept. of Pharmacognosy KLES College of Pharmacy, Belgaum, Karnataka, India. Emailjadhavanil_29@rediffmail.com Ph. No. 09909220894.

Online published on 20 March, 2013.

Abstract

In recent times lot of interest has been generated to find out a natural remedy for hepatic disorders caused by toxins like alcohol and hepatitis virus. The present study is designed and investigate the hepatoprotective activity of Bauhinia variegata bark against carbon tetrachloride (CCl4) induced hepatotoxicity in female Albino Wistar rats. Forty two Albino Wistar female rats were divided in to seven equal groups each containing six animals. Four groups received the extracts of Bauhinia variegata bark and intraperitoneal (i.p.) CCl4 (2 ml/kg) with administration of extracts. One group was control, one treated with CCl4 and one with normal saline. The hepatotoxicity was assessing by plasma concentration of serum bilirubin and enzymes activities. The aqueous extract (500mg/kg b.w) of Bauhinia variegata bark significantly reduced carbon tetrachloride induce damages in the liver which is measured by SGOT, SGPT, SALP and serum bilirubin levels in blood. The attempt has been made to extract the active constituent and identified by phytochemical investigation and hepatoprotective activity of Bauhinia variegata bark.

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Keywords

Bauhinia variegata, carbon tetrachloride, hepatoprotective.

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