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Research Journal of Pharmacology and Pharmacodynamics
Year : 2010, Volume : 2, Issue : 3
First page : ( 221) Last page : ( 227)
Print ISSN : 0975-4407.

Oxidative Stress in Diabetes-A Key Therapeutic Agent

Vadivelan R.*, Dhanabal S.P., Rajeswari Raja, Shanish A., Elango K., Suresh B.

J.S.S. College of Pharmacy (Off Campus of JSS University, Mysore) Ooty, Nilgiris-643001

*Corresponding Author: Mr.R.Vadivelan M.Pharm, Assistant Professor, Department of Pharmacology, J.S.S. College of Pharmacy, (Off Campus of JSS University, Mysore) Ooty, Nilgiris – 643 001. M-09047539532 Email: rv_sofia@rediffmail.com

Online published on 20 March, 2013.


Oxidative stress (OS) has been repetitively shown to be a hallmark of many diseases linked with metabolic or vascular disorders. It is produced under diabetic condition and is involved in the progression of pancreatic damage in diabetes. Therefore diabetes represents an ideal candidate for studying the consequences of oxidative stress and its treatment. Diabetes constitutes a multiple source of free radicals, starting very early in the disease, oxidative stress is exposed to have a double impact; on both metabolic and vascular functions. This review describes the many different aspects of oxidative stress in diabetes and proposes possible explanations for the apparent lack of efficacy of antioxidant treatments.



Oxidative stress, Antioxidants, Diabetes.


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