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Research Journal of Pharmacology and Pharmacodynamics
Year : 2020, Volume : 12, Issue : 2
First page : ( 91) Last page : ( 96)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2020.00018.X

Pharmacological Evaluation of Livodac Tablet on Ethanol Induced Hepatotoxicity Models in Wistar Rats

Jagtap Pradnya. N.*, Chavan Prachali Ramdas, Dr. shitole Suhas

Pune District Education Association's, Seth Govind Raghunath Sable College of Pharmacy, Saswad, 412301, Tal. Purandar, Dist. Pune, Maharashtra, India.

*Corresponding Author E-mail: prachalichavan@gmail.com

Online published on 10 August, 2020.

Abstract

The various pharmaceutical dosages are affected on human health after long time or repeated use. Ethanol induce the toxicity to liver to use in high dose. These study was describe the significant effect of livodac formulation on Ethanol induced liver cirrhosis in rats. The thirty six animal were grouped in six set (1) Normal controle, it kept at normal condition (2) Disease controle group contains 50% Ethanol (2ml/kg) (3) Standard group Silyamarin gives with 50% Ethanol (2ml/kg) (4) Test drug (100mg/kg) with 50% Ethanol (2ml/kg) (5) Test drug (200mg/kg) with 50% Ethanol (2ml/kg) (6) Test drug (400mg/kg) with 50% Ethanol (2ml/kg). The present study show result of three dosage of livodac formulation should be significantly reduce the level of SGOT, SGPT, Total bilirubin, Total protein, Alkaline phosphate in the induce hepatotoxic model. The given livodac formulation effectively used as hepatoprotective agent in the management of liver cirrhosis caused by to various used drugs.

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Keywords

Pharmaceutical dosages, Ethanol, Hepatoprotective, Liver cirrhosis, livodac.

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