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Research Journal of Pharmacology and Pharmacodynamics
Year : 2020, Volume : 12, Issue : 2
First page : ( 88) Last page : ( 90)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2020.00017.8

Spectrophotometric Methods for Estimation of Artesunate from Tablet Dosage forms by Hydrotrophy

Anekar V. P.1,,*, Mohite P. M.1, Sankpal P. S.2

1Govt. College of Pharmacy, Karad (M.S.) India

2Vasantidevi Patil Institute College of Pharmacy, Kodoli, Kolhapur (M.S.) India.

*Corresponding Author E-mail: vaishnavianekar8@gmail.com

Online published on 10 August, 2020.

Abstract

Quantitative estimation of poorly water-soluble drugs involves use of organic solvents. Major drawbacks of organic solvents include high cost, volatility and toxicity. In the present investigation, hydrotropic solubilization is employed to enhance the aqueous solubilities of poorly water-soluble drugs like artesunate in tablet dosage forms. This method utilizes 2.0 M urea solution as, hydrotropic solubilizing agent. In the urea solution artesunate shows maximum absorbance at 242nm. The 2.0M urea solution does not show any interference with the sampling wavelength. The hydrotropic agent and additives used in the manufacture of tablets did not interfere in the analysis. The results of tablet analysis were found be in range of 98.56 to 101.02% by hydrotropy. The results of analysis of both methods were validated statistically following ICH guidelines.

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Keywords

Artesunate, Urea, Hydrotropy.

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