Biochemical Estimation of High Dose of Omeprazole in Experimental Rodents. Kumar G. Sarvan1,*, Swathi S.2, Prasanna B. Laxmi2, M. Kumari Prathima2, Dr. Suthakaran R.3 1Associate Professor, Department of Pharmacology, Vijaya College of Pharmacy, Hyderabad 2Department of Pharmacology, Vijaya College of Pharmacy, Hyderabad 3Principal and Professor, Department of Pharmaceutical Analysis, Vijaya College of Pharmacy, Hyderabad *Corresponding Author E-mail: sarvanpharma@gmail.com
Online published on 31 December, 2019. Abstract This study was carried out to evaluate the effect of high dose of omeprazole (100mg/kg) on biochemical parameters of liver in albino rats. Albino wistar rats were given into three groups, consisting of 6 animals per group and treated with normal saline (5mg/kg), omeprazole (100mg/kg) and silymarin (25mg/kg) respectively for 14 days. The rats were sacrificed on 14th day and the serum were collected and estimated for liver parameters. Results showed that rats administrated with omeprazole (100mg/kg) exhibited a significant increase (p< 0.0001). In the levels of SGOT, SGPT, ALP, TB, TP, SC compared with controlled rats and total protein was decreased (p<0.05). histology result of rats in remarkable centrilobular necrosis, confirmed hepatic damage. In conclusion data obtained from this present research indicates that omeprazole at high dose (100mg/kg) may be capable of inducing hepatic cellular damage as evident from histopathological findings. Although further study is required to establish a possible pharmacological mechanism in some other animal species Top Keywords Omeprazole, Liver Biochemistry, Liver Histology. Top |