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Research Journal of Pharmacology and Pharmacodynamics
Year : 2019, Volume : 11, Issue : 2
First page : ( 51) Last page : ( 61)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2019.00010.7

Comparative Hypoglycemic effects of aqueous leaf extracts of Vernonia amygdalina, Ocimum gratissimum, Phyllanthus amarus, Gongronema latifolum, Piper nigrum and Solanum melongena on Blood Glucose Level of Alloxan-Induced Diabetic Guinea Pigs

Wariso C Akunneh1,*, Aduema W2

1Department of Human Physiology, Abia State University, Uturu, Abia State, Nigeria

2Department of Medical Physiology, PAMO University of Medical Sciences, Port Harcourt, Rivers State, Nigeria

*Corresponding Author E-mail: Wadioniaduema@gmail.com

Online published on 31 December, 2019.

Abstract

This research work was meant to explore the hypoglycemic potencies of different tropical herbal aqueous leaf extract of Vernonia amygdalina (Bitter lea), Phyllanthus amarus (Stone breaker), Ocimum gratissimum (Sent leaf), Gongronema latifolium (Utazi), Piper nigrum (Uziza) and Solanum melongena (Gardern egg) on blood sugar level of alloxan induced diabetic guinea pigs. Seventy guinea pigs of both male and female were randomly selected and grouped accordingly using Glibenclamide solution (a known oral hypoglycemic drug) as a positive control and physiological solution (0.9% Normal Saline) as a negative control. The average weight of the guinea pigs was 250g. each guinea pig was made diabetic by induction with a single dose of 5% alloxan monohydrate dissolved in 0.9% normal saline at 200mg/kg body weight intraperitoneally. This concentration of alloxan used for diabetic induction in these guinea pigs was determined during the preliminary test. Six different groups had oral administration of the aqueous leaf extract via Canula at 300mg/kg body weight per day for two weeks after alloxan induction. The positive and negative control groups had oral administration of glibenclamide solution (a know oral hypoglycemic agent) at 0.25mg/day and 0.9% NS (a physiological solution) at 15ml/day via canula for two weeks respectively. On the average, the results of this study revealed appreciable percentage reduction of fasting blood sugar level of the diabetic guinea pigs that had oral administration of aqueous leaf extracts of Phyllanthus amarus, Vernonia amygdalina, Gongronema latifolium and Ocimum gratissimum which was comparable to the fasting blood sugar level of positive control group (Glibernclamide solution), thereby showing an appreciable hypoglycemic effects. The group of diabetic guinea pigs that had aqueous leaf extracts of Solanum melongena had a low percentage reduction which depicts mild hypoglycemic effects, while the group that had Piper nigrum showed a very insignificant percentage of reduction of mean fasting blood sugar. The effect seen in this group that had aqueous leaf extract of piper nigrum was comparable to the effect seen in negative control group. Z-test as a statistical test revealed a significant difference between the post induction fasting blood sugar level and post aqueous leaf extract administration (p< 0.05).

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Keywords

Hypoglycemic, alloxan-induced, bood glucose level.

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