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Research Journal of Pharmacology and Pharmacodynamics
Year : 2018, Volume : 10, Issue : 4
First page : ( 156) Last page : ( 158)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2018.00028.9

Influence of dietary substances on recognition memory in Albino mice

Kumar Kadiri Sunil1,*, Suthakaran R.1, Bairam Ravindar2

1Department of Pharmacology and Pharmaceutical Chemistry, Vijaya College of Pharmacy, Munaganoor, 501511, Hyderabad, Telangana, India

2Department of Pharmaceutical Chemistry, Vignan Institute of Pharmaceutical Sciences, Near Ramoji Film City, Deshmukhi, Nalgonda, Telangana State-50828, India

*Corresponding Author E-mail: sunil.cology@gmail.com

Online published on 27 December, 2018.


The present investigation was designed to evaluate the effects of dietary substances such as Saccharin (100 mg/kg, p.o), Turmeric (1g/kg, p.o) and Transfat (2%, p.o) on recognition memory in albino mice by employing Y maze test. The test mice were treated with the above dietary substances for a period of 30 days. Control mice received distilled water, p.o for 30 days. Standard mice received cerebroactive drug Donepezil (1mg/kg, p.o) for 30 days. The assessment of memory commences on 31st day by placing each mouse in the centre of the Y maze apparatus for 5 minutes and the memory parameters like spontaneous alteration performance (SAP), alternate arm return (AAR) and same arm return (SAR) were recorded. SAP which is a measure of memory was found to be lower with transfat (15±0.01) and saccharin (14±1.21) when compared to control mice (20±0.12) indicating loss of memory with transfat and saccharin. Turmeric treated mice displayed a significant increase in SAP (30±0.75) than the control mice indicating memory enhancing potential of turmeric. However SAP of donepezil treated mice was found to be more (34±0.04) than the turmeric treated mice.



Recognition memory, saccharin, turmeric, transfat, Donepezil, SAP.


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