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Research Journal of Pharmacology and Pharmacodynamics
Year : 2018, Volume : 10, Issue : 2
First page : ( 66) Last page : ( 68)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2018.00011.3

Hydro alcoholic extract of Punica granatum for anthelmintic activity

Ibrahim Syed**, Abrar Mohammed, Roshan S*

Deccan School of Pharmacy, Aghapura, Hyderabad-01, India

*Corresponding Author E-mail: Roshansalfi@yahoo.com,

**ibrahimsyed338@gmail.com

Online published on 7 July, 2018.

Abstract

The present study was aimed to investigate the anthelmintic potential of Hydro alcoholic Punica granatum Peel extract on Indian earth-worm Pheretima posthuma. Three concentrations (100, 150, 200 mg/ml) of extract were studied in activity which involved the determination of time of paralysis (vermifuge) and time of death (vermicidal) of the worms. Albendazole (20 mg/ml) in same concentration as those of extract was included as standard reference and normal saline water with 0.5% w/v CMC as control. The extracts exhibited significant anthelmintic activity at a concentration of 150, 200 mg/ml. Peak activity was exhibited by the Hydro alcoholic extract at a concentration of 200 mg/ml, respectively dose-dependent action and inhibition of spontaneous motility (paralysis) and death of earthworms Findings of the present investigations confirms that, the ethnomedicinal claim of anthelmintic activity of this plant is genuine.

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Keywords

Punica granatum, Anthelmintic activity, Albendazole, Vermifuge, Vermicidal.

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