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Research Journal of Pharmacognosy and Phytochemistry
Year : 2017, Volume : 9, Issue : 2
First page : ( 121) Last page : ( 124)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.
Article DOI : 10.5958/0975-4385.2017.00022.X

Hepatoprotective activity of Bridelia retusa bark extracts against carbon tetrachloride-induced liver damage rats.

Ghawate V. B.1,2,*, Shrivastava Purnima1, Bhambar R.S.3

1Department of Pharmaceutical Sciences, Bhagwant University, Ajmer, Rajasthan

2Department of Pharmacognosy, MES College of Pharmacy, Sonai, Ahmednagar, Maharashtra

3MGV's College of Pharmacy, Panchwati, Nasik, Maharashtra

*Corresponding Author E-mail: vilasghawate@rediffmail.com

Online published on 17 July, 2017.


The present study is aimed to evaluate the hepatoprotective effect of Bridelia retusa bark extracts against carbon tetrachloride-induced liver damage in rats. The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and bilirubin. Treatment with Bridelia retusa bark butanol extract (200mg/kg b.w. p.o.) showed significant reduction in level of SGOT, SGPT, ALP and total bilirubin almost comparable to the Silymarin. The hepatoprotection confirmed by histopathological examination of the liver tissue. From the result it can be concluded that Bridelia retusa bark extract possesses hepatoprotective effect against carbon tetrachloride-induced liver damage in rats.



Bridelia retusa, Hepatoprotection, carbon tetrachloride, Silymarin.


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