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Research Journal of Pharmacognosy and Phytochemistry
Year : 2017, Volume : 9, Issue : 2
First page : ( 111) Last page : ( 114)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.
Article DOI : 10.5958/0975-4385.2017.00020.6

Evaluation of analgesic potential of Boerhavia diffusa roots in albino mice

Kumar Kadiri Sunil1,*, Saideepthi V.2, Shahajeb Shaik2, Nandini M.2, Suthakaran R.3

1Associate Professor, Department of Pharmacology, Vijaya College of Pharmacy, Munaganoor-501511, Hyderabad, Telangana, India

2B-Pharmacy Final year II Sem, Vijaya College of Pharmacy, Munaganoor-501511, Hyderabad, Telangana, India

3Principal and Professor, Department of Pharmaceutical Chemistry, Vijaya College of Pharmacy, Munaganoor-501511, Hyderabad, Telangana, India

*Corresponding Author E-mail: sunil.cology@gmail.com

Online published on 17 July, 2017.

Abstract

The present research was designed to evaluate the analgesic potential of Boerhavia diffusa root powder 150 mg/kg, p.o in albino mice. Boerhavia diffusa is a popular herb in ayurveda which is also known as Punarnava. Boerhavia diffusa root powder was procured from a local ayurvedic store. The analgesic effect of the root powder was evaluated by using acetic acid induced writhings test in mice. It was found that Boerhavia diffusa root powder at a dose of 150 mg/kg treated for 15 days has significantly inhibited pain induced by acetic acid by decreasing the number of writhing responses such as extension of hind limbs (22±0.77), abdominal constrictions (13±0.08) and trunk twisting (20±0.55) when compared to control treated mice i.e extension of hind limbs (38±0.17), abdominal constrictions (26±1.23) and trunk twisting (24±0.55) in control mice. The results were compared with standard diclofenac sodium (25 mg/kg, p.o) treated mice. Hence it is evident from the above results that boerhavia diffusa at 150 mg/kg possesses significant analgesic potential.

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Keywords

Boerhavia diffusa, analgesic, writhing responses, acetic acid, diclofenac sodium.

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