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Research Journal of Pharmacognosy and Phytochemistry
Year : 2011, Volume : 3, Issue : 2
First page : ( 77) Last page : ( 81)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.

Hepatoprotective Activity of Vitex quinata Roots against Paracetamol-Induced Hepatic Injury in Rats.

Sreedhar V.1,*, Nath L.K. Ravindra2, Gopal N. Madana1, Gopal K. Venu3, Raju D.1, Rajasekhar K.K.4

1Department of Pharmacy, Prabhath Institute of Pharmacy, Nandayal, A.P, INDIA

2Department of Chemistry, Srikrishna Devaraya University, Anantapur, A.P, INDIA

3Dept of Pharmacy, Nirmala College of Pharmacy, Kadapa, Andhra Pradesh, INDIA

4Departement Of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupathi-517503, A.P, INDIA

*Corresponding Author: V. Sreedhar Deparment of Pharmacy, Prabhath Institute of Pharmacy, Nandayal, A.P, INDIA E-mail: veerasree@yahoo.com, Phone no: +91-9441190175

Online published on 21 March, 2013.

Abstract

Methanolic extracts of Vitex quinata roots at 200, 400 and 800 mg/kg and silymarin was prepared and tested for its hepatoprotective effect against paracetamol induced hepatitis in rats. Alteration in the level of biochemical markers of hepatic damage like SGOT, SGPT, ALKP, TPL, CHL, TPTN and ALP were tested in both treated and untreated groups. The methanolic extracts of Vitex quinata roots at 200,400 and 800 mg/kg and silymarin showed a significant (P<0.05) decrease in all the elevated SGOT, SGPT, ALKP, TBL, CHL and significant increase (P<0.05) in TPTN and ALB levels produced by the toxicant Paracetamol.

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Keywords

Vitex quinata, Antioxidant activity, Ascorbic acid.

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