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Research Journal of Pharmacognosy and Phytochemistry
Year : 2011, Volume : 3, Issue : 2
First page : ( 75) Last page : ( 76)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.

Hepatoprotective Activity of Prunus persica Peaches against Paracetamol Induced Hepatotoxicity.

Manokaran S.*, Saravanan V.S., Bhargavi Y.

The Erode College of Pharmacy, Tamilnadu

*Corresponding Author: Mr. S. Manokaran, M. Pharm., Dept. of Pharmacognosy, The Erode College of Pharmacy, Veppampalayam, Vallipurathan Palayam (PO), Erode – 638 112. Tamilnadu, India. Mobile No: +919626056858 E-mail: msellimuthu@gmail.com

Online published on 21 March, 2013.

Abstract

Hepato-toxicity is a common toxicity happening during the treatment of chronic disease like tuberculosis, diabetics. Prunus persica belongs to Rosaceae is a plant growing in temperate region has laxative, sedative, anticancer property and also consist of glycosides, flavonoids, anthocyanins, vitamins. It also posses hepato-protactent property. To prove the activity scientifically the ethanolic extract of Prunus persica was studied against paracetamol induced hepatotoxicity in albino rats. The extract when evaluated at dose of 100mg/kg was found to significantly reduce the elevated levels of serum lysosomal enzyme Sgpt, Sgot, Alp and Bilirubin when compared with standard silymarin.

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Keywords

Prunus persica, paracetamol, albino rats, serum enzymes.

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