Hepatoprotective and Antioxidant Potential of Extracts from Whole Plant of Solanum surattense Burm Patil Suhas A.*, Joshi V.G., Sambrekar S.N., Desai N. S. Maratha Mandal's College of Pharmacy, Belgaum, India *Corresponding Author: Patil Suhas A. Asst. Prof, Dept of Pharmacognosy, Maratha Mandal's College of Pharmacy, Belgaum.560010. Karnataka, India. Phone: 9448230534, E-mail: mrsuhaspatil@rediffmail.com
Online published on 21 March, 2013. Abstract Objectives Alcoholic and aqueous extracts of Solanum surattense Burm were investigated for their Hepatoprotective and Antioxidant potentials against Liver injury induced by CCl4 in rats. Methods The liver damage was induced in male albino rats (150-200g) by administering CCl4 (2ml/kg) for 7 days and extent of damage was studied by assessing biochemical and Antioxidant level in liver parameters such as aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin, lipid peroxidase (LPO) with a reduction of total protein, superoxide dismutase (SOD), catalase, and glutathione Stransferase (GST) in experimental animals. Histopathological changes of liver sample were compared with respective control. Results Treatment of rats with alcoholic and aqueous plant extract (200mg/kg) for 7 days resulted in significant (P<0.001) reduction in serum marker enzymes and antioxidant levels to near normal against CCl4-treated rats. The protection effect was found to be comparable with Liv52 treated group. Conclusion The alcoholic extracts of Solanum surattense Burm have protected liver from CCl4 damage. The probable mechanism may be due to Steroid and Tannins known for their Antioxidant activity may potentially confer protection against oxidative stress induced liver injury. Top Keywords Hepatoprotective, Antioxidant, Solanum surattense Burm, Carbon tetrachloride, Biochemical parameters, Histopathology. Top |